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Phenocal Clinical Studies

Hoodia Gordonii

A specific component of hoodia extract is thought to be responsible for appetite suppressant properties. This constituent has been dubbed P57. This substance is thought to act centrally to stimulate sensations of satiety.

1. Mangold T. Sampling the Kalahari cactus diet. BBC News; May 30, 2003.

Preliminary unpublished evidence suggests that overweight men who consume P57 have significantly lower calorie intake than those on placebo

1.Phytopharm plc successful completion of proof of principle clinical study of P57 for Obesity. Phytopharm Press Release; December 5, 2001.

Green Tea Extract

  1. Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 2004;18:55-62.
     
  2. Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr 2004;79:40-6.
     
  3. Chantre P, Lairon D. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 2002;9:3-8.
     
  4. Cronin JR. Green tea extract stokes thermogenesis: will it replace ephedra? Altern Comp Ther 2000;6:296-300.

Green tea increases energy expenditure and fat oxidation.

1. Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999; 70:1040-5.

5-HTP

Preliminary evidence suggests that taking 5-HTP orally might help reduce appetite, caloric intake, and weight in obese patients

1. Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7.

Glucomannan

There is preliminary evidence that taking glucomannan orally might help reduce weight in obese children and adults.
  1. Livieri C, Novazi F, Lorini R. [The use of highly purified glucomannan-based fibers in childhood obesity]. [Article in Italian]. Pediatr Med Chir 1992;14:195-8.
     
  2. Vita PM, Restelli A, Caspani P, et al. [Chronic use of glucomannan in the dietary treatment of severe obesity]. [Article in Italian]. Minerva Med 1992;83:135-9.
    Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes 1984;8:289-93.
     
  3. Cairella M, Marchini GAD. [Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients]. [Article in Italian]. Clin Ter 1995;146:269-74.
     
  4. McCarty MF Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy. Med Hypotheses. 2002 Jun;58(6):487-90
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